The kinome ?at large? in cancer
Over the last decade, rapid advances in genomics, proteomics and functional genomics technologies that enable in-depth interrogation of cancer genomes and proteomes and high-throughput analysis of gene function have enabled characterization of the kinome ?at large? in human cancers, providing critical insights into how members of the protein kinase superfamily are dysregulated in malignancy, the context-dependent functional role of specific kinases in cancer, and how kinome remodeling modulates sensitivity to anti-cancer drugs. The power of these complementary approaches, and the insights gained from them, form the basis of this article.
|Authors||Fleuren, E.D.G; Zhang, L.; Wu, J.; Daly, R.J.|
|Publisher Name||NAT REV CANCER|
|Published Date||2016-01-01 00:00:00|