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Dedicator of cytokinesis 8-deficient CD4+ T cells are biased to a TH2 effector fate at the expense of TH1 and TH17 cells.

Abstract

Dedicator of cytokinesis 8 (DOCK8) deficiency is a combined immunodeficiency caused by autosomal recessive loss-of-function mutations in DOCK8. This disorder is characterized by recurrent cutaneous infections, increased serum IgE levels, and severe atopic disease, including food-induced anaphylaxis. However, the contribution of defects in CD4+ T cells to disease pathogenesis in these patients has not been thoroughly investigated.

Type Journal
Authors Tangye, SG.; Pillay, B.; Randall, L.; Avery, DT.; Phan, TG.; Gray, P.; Ziegler, JB.; Smart,JM.; Choo, S.; Peake, J.; Arkwright,PD.; Hambleton, S.; Oswaldo Lugo Reyes, S.; Orange, J.; Freeman, AF.; Uzel, G.; Su, HC.; Goodnow, CG.; Casanova, JL.; Ma, CS.
Responsible Garvan Author Prof Stuart Tangye
Publisher Name JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
Published Date 2017-03-01
Published Volume 139
Published Pages 933-949
Status Published in-print
DOI 10.1016/j.jaci.2016.07.016
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/13432