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Endogenous microRNA sponges: evidence and controversy

Abstract

The competitive endogenous RNA (ceRNA) hypothesis proposes that transcripts with shared microRNA (miRNA) binding sites compete for post-transcriptional control. This hypothesis has gained substantial attention as a unifying function for long non-coding RNAs, pseudogene transcripts and circular RNAs, as well as an alternative function for messenger RNAs. Empirical evidence supporting the hypothesis is accumulating but not without attracting scepticism. Recent studies that model transcriptome-wide binding-site abundance suggest that physiological changes in expression of most individual transcripts will not compromise miRNA activity. In this Review, we critically evaluate the evidence for and against the ceRNA hypothesis to assess the impact of endogenous miRNA-sponge interactions.

Type Journal
Authors Thomson, D. W.; Dinger, M. E.
Publisher Name NAT REV GENET
Published Date 2016-05-17 00:00:00
Published Volume 17
Published Issue 5
Published Pages 272-83
URL http://www.ncbi.nlm.nih.gov/pubmed/27040487
Status Published in-print