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The Lymph node neutrophil

Abstract

Secondary lymphoid organs provide a specialized microenvironment tailored to foster communication between cells of the innate and adaptive immune systems. These interactions allow immune cells to coordinate multilayered defense against pathogens. Until recently dendritic cells and macrophages were thought to comprise the main innate immune cell subsets responsible for delivering signals that drive the adaptive immune response, while the function of neutrophils was largely confined to the innate immune system. However, the discovery of neutrophils in lymph nodes has raised the question of whether neutrophils might play a more extensive role not only in innate immunity per se, but also in coordinating the interactions between innate and adaptive immune responses. In this review we discuss the mechanisms and consequences of neutrophil recruitment to lymph nodes and how this recruitment influences subsequent immune responses both in situ and at distant sites.

Type Journal
Authors Hampton, H.; Chtanova, T.
Publisher Name SEMIN IMMUNOL
Published Date 2016-04-01 00:00:00
Published Volume 28
Published Issue 2
Published Pages 129-136
URL http://www.ncbi.nlm.nih.gov/pubmed/27025975
Status Published in-print