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Bone metastasis: the importance of the neighbourhood


During the past decade preclinical studies have defined many of the mechanisms used by tumours to hijack the skeleton and promote bone metastasis. This has led to the development and widespread clinical use of bone-targeted drugs to prevent skeletal-related events. This understanding has also identified a critical dependency between colonizing tumour cells and the cells of bone. This is particularly important when tumour cells first arrive in bone, adapt to their new microenvironment and enter a long-lived dormant state. In this Review, we discuss the role of different bone cell types in supporting disseminated tumour cell dormancy and reactivation, and highlight the new opportunities this provides for targeting the bone microenvironment to control dormancy and bone metastasis.

Type Journal
ISBN 1474-1768 (Electronic) 1474-175X (Linking)
Authors Croucher, P. I.; McDonald, M. M.; Martin, T. J.;
Published Date 2016-05-01
Published Volume 16
Published Issue 6
Published Pages 373-86
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version