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Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans


High abundance of brown adipose tissue (BAT) is linked to lower glycaemia in humans, leading to the belief that BAT may protect against diabetes. The relationship between BAT glucose utilization and systemic glucose homeostasis has not been defined. In this paper we have characterized glycaemic excursions and BAT thermogenic responses in human brown adipocytes, BAT explants, and healthy adults through supraclavicular temperature profiling, revealing their circadian coupling in vivo and in vitro, orchestrated by UCP1, GLUT4, and Rev-erbalpha biorhythms. Extent of glycated haemoglobin also correlated positively with environmental temperature among community-dwelling patients. These data uncover potential crosstalk between BAT and glucose regulatory pathways, evident on cellular, tissue, individual, and population levels, and provide impetus to search for BAT harnessing strategies for therapeutic purposes.

Type Journal
ISBN 1932-7420 (Electronic) 1550-4131 (Linking)
Authors Lee, P.; Bova, R.; Schofield, L.; Bryant, W.; Dieckmann, W.; Slattery, A.; Govendir, M. A.; Emmett, L.; Greenfield, J. R.;
Responsible Garvan Author (missing name)
Publisher Name Cell Metabolism
Published Date 2016-04-01
Published Volume 23
Published Issue 4
Published Pages 602-9
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version