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International survey of awareness of genetic risk in the clinical sarcoma community


AIM: Integration of clinical genetics into oncology is variable. Sarcomas have a strong genetic component, with up to 1/30 patients carrying germline TP53 mutations. This study aimed to define genetic risk awareness among sarcoma physicians. Outcomes were attitudes toward genetic testing, level of cancer risk and awareness of risk reduction measures. METHODS: An online survey was administered to members of the Connective Tissue Oncology Society and the Australasian Sarcoma Study Group. RESULTS: Sarcoma physicians (N = 124) from 21 countries participated, 40% of whom favored TP53 mutation testing in children regardless of family history, increasing to approximately 83% for all age groups if a family history was present and approximately 85% if multiple primary cancers were present. However, 33% were not aware that risk reduction strategies might identify some cancers at a more curable stage in carriers. CONCLUSION: Clinical genetics is not yet standard of care for multidisciplinary management of sarcoma. Awareness of genetic risk is important among sarcoma physicians. Attitudes among the sarcoma community were generally positive, but education on genetic risk in sarcoma patients and collaboration with clinical genetics services might improve quality of care. Sarcoma physicians need routine access to clinical genetics services so that potential germline TP53 mutation carriers are recognized.

Type Journal
ISBN 1743-7563 (Electronic) 1743-7555 (Linking)
Authors McBride, K. A.; Schlub, T. E.; Ballinger, M. L.; Thomas, D. M.; Tattersall, M. H.;
Publisher Name Asia-Pacific Journal of Clinical Oncology
Published Date 2016-06-01
Published Volume 12
Published Issue 2
Published Pages 133-42
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version