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Metabolic syndrome, diet and exercise

Abstract

Polycystic ovary syndrome (PCOS) is associated with a range of metabolic complications including insulin resistance (IR), obesity, dyslipidaemia, hypertension, obstructive sleep apnoea (OSA) and non-alcoholic fatty liver disease. These compound risks result in a high prevalence of metabolic syndrome and possibly increased cardiovascular (CV) disease. As the cardiometabolic risk of PCOS is shared amongst the different diagnostic systems, all women with PCOS should undergo metabolic surveillance though the precise approach differs between guidelines. Lifestyle interventions consisting of increased physical activity and caloric restriction have been shown to improve both metabolic and reproductive outcomes. Pharmacotherapy and bariatric surgery may be considered in resistant metabolic disease. Issues requiring further research include the natural history of PCOS-associated metabolic disease, absolute CV risk and comparative efficacy of lifestyle interventions.

Type Journal
ISBN 1532-1932 (Electronic) 1521-6934 (Linking)
Authors De Sousa, S. M. Dr; Norman, R. J. Prof;
Publisher Name BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
Published Date 2016-01-01
Published Volume 37
Published Pages 140-151
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/26972165
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/13809