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The majority of murine gammadelta T cells at the maternal-fetal interface in pregnancy produce IL-17

Abstract

Compared with lymphoid tissues, the immune cell compartment at mucosal sites is enriched with T cells bearing the gammadelta T-cell receptor (TCR). The female reproductive tract, along with the placenta and uterine decidua during pregnancy, are populated by gammadelta T cells predominantly expressing the invariant Vgamma6(+)Vdelta1(+) receptor. Surprisingly little is understood about the function of these cells. We found that the majority of gammadelta T cells in the non-pregnant uterus, pregnant uterus, decidua and placenta of mice express the transcription factor RORgammat and produce interleukin-17 (IL-17). In contrast, IFNgamma-producing gammadelta T cells were markedly reduced in gestational tissues compared with uterine-draining lymph nodes and spleen. Both uterine-resident invariant Vgamma6(+) and Vgamma4(+) gammadelta T cells which are more typically found in lymphoid tissues and circulating blood, were found to express IL-17. Vgamma4(+) gammadelta T cells were particularly enriched in the placenta, suggesting a pregnancy-specific recruitment or expansion of these cells. A small increase in IL-17-producing gammadelta T cells was observed in allogeneic compared with syngeneic pregnancy, suggesting a contribution to regulating the maternal response to paternally-derived alloantigens. However, their high proportions also in non-pregnant uteri and gestational tissues of syngeneic pregnancy imply a role in the prevention of intrauterine infection or quality control of fetal development. These data suggest the need for a more rigorous evaluation of the role of IL-17 in sustaining normal pregnancy, particularly as emerging data points to a pathogenic role for IL-17 in pre-eclampsia, pre-term birth, miscarriage and maternal immune activation-induced behavioral abnormalities in offspring.

Type Journal
ISBN 1440-1711 (Electronic) 0818-9641 (Linking)
Authors Pinget, G. V.; Corpuz, T. M.; Stolp, J.; Lousberg, E. L.; Diener, K. R.; Robertson, S. A.; Sprent, J.; Webster, K. E.;
Responsible Garvan Author Dr Kylie Webster
Publisher Name IMMUNOLOGY AND CELL BIOLOGY
Published Date 2016-01-01 00:00:00
Published Volume 94
Published Issue 7
Published Pages 623-30
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/27241697
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/13823