The majority of murine gammadelta T cells at the maternal-fetal interface in pregnancy produce IL-17
Compared with lymphoid tissues, the immune cell compartment at mucosal sites is enriched with T cells bearing the gammadelta T-cell receptor (TCR). The female reproductive tract, along with the placenta and uterine decidua during pregnancy, are populated by gammadelta T cells predominantly expressing the invariant Vgamma6(+)Vdelta1(+) receptor. Surprisingly little is understood about the function of these cells. We found that the majority of gammadelta T cells in the non-pregnant uterus, pregnant uterus, decidua and placenta of mice express the transcription factor RORgammat and produce interleukin-17 (IL-17). In contrast, IFNgamma-producing gammadelta T cells were markedly reduced in gestational tissues compared with uterine-draining lymph nodes and spleen. Both uterine-resident invariant Vgamma6(+) and Vgamma4(+) gammadelta T cells which are more typically found in lymphoid tissues and circulating blood, were found to express IL-17. Vgamma4(+) gammadelta T cells were particularly enriched in the placenta, suggesting a pregnancy-specific recruitment or expansion of these cells. A small increase in IL-17-producing gammadelta T cells was observed in allogeneic compared with syngeneic pregnancy, suggesting a contribution to regulating the maternal response to paternally-derived alloantigens. However, their high proportions also in non-pregnant uteri and gestational tissues of syngeneic pregnancy imply a role in the prevention of intrauterine infection or quality control of fetal development. These data suggest the need for a more rigorous evaluation of the role of IL-17 in sustaining normal pregnancy, particularly as emerging data points to a pathogenic role for IL-17 in pre-eclampsia, pre-term birth, miscarriage and maternal immune activation-induced behavioral abnormalities in offspring.
|ISBN||1440-1711 (Electronic) 0818-9641 (Linking)|
|Authors||Pinget, G. V. ; Corpuz, T. M. ; Stolp, J. ; Lousberg, E. L. ; Diener, K. R. ; Robertson, S. A. ; Sprent, J. ; Webster, K. E.;|
|Responsible Garvan Author|
|Publisher Name||IMMUNOLOGY AND CELL BIOLOGY|
|URL link to publisher's version||http://www.ncbi.nlm.nih.gov/pubmed/27241697|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/13823|