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CAST your vote: is calpain inhibition the answer to ALS?

Abstract

A publication in the Journal of Neurochemistry by Rao et al. (2016) suggests that the overexpression of the calpain inhibitor, calpastatin (CAST) rescues neuron loss and increases survival of the amyotrophic lateral sclerosis (ALS) mouse model, hSOD1G93A. The findings of Rao et al. (2016) provide an insight into the mechanisms that lead to neuronal loss in ALS and suggest a cell loss pathway common to several neurodegenerative disorders that may be therapeutically targeted. Here, we highlight the findings of Rao et al. (2016) and discuss some key considerations required prior to assessing the potential use of calpain inhibitors in the clinic. Read the highlighted article 'Calpastatin inhibits motor neuron death and increases survival in hSOD1(G93A) mice' on page 253.

Type Journal
ISBN 1471-4159 (Electronic) 0022-3042 (Linking)
Authors Wright, A. L.; Vissel, B.;
Publisher Name J NEUROCHEM
Published Date 2016-01-01 00:00:00
Published Volume 137
Published Issue 2
Published Pages 140-1
URL http://www.ncbi.nlm.nih.gov/pubmed/27005822
Status Published In-print
OpenAccess Link https://publications.gimr.garvan.org.au/download.php?13909_13730/2016-Wright-J Neurochem.pdf