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Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes

Abstract

Chromium(III) nutritional supplements are widely consumed for their purported antidiabetic activities. X-ray fluorescence microscopy (XFM) and X-ray absorption near-edge structure (XANES) studies have now shown that non-toxic doses of [Cr3 O(OCOEt)6 (OH2 )3 ](+) (A), a prospective antidiabetic drug that undergoes similar H2 O2 induced oxidation reactions in the blood as other Cr supplements, was also oxidized to carcinogenic Cr(VI) and Cr(V) in living cells. Single adipocytes treated with A had approximately 1 mum large Cr hotspots containing Cr(III) , Cr(V) , and Cr(VI) (primarily Cr(VI) thiolates) species. These results strongly support the hypothesis that the antidiabetic activity of Cr(III) and the carcinogenicity of Cr(VI) compounds arise from similar mechanisms involving highly reactive Cr(VI) and Cr(V) intermediates, and highlight concerns over the safety of Cr(III) nutritional supplements.

Type Journal
ISBN 1521-3773 (Electronic) 1433-7851 (Linking)
Authors Wu, L. E.; Levina, A.; Harris, H. H.; Cai, Z.; Lai, B.; Vogt, S.; James, D. E.; Lay, P. A.;
Publisher Name ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Published Date 2016-01-01 00:00:00
Published Volume 55
Published Issue 5
Published Pages 1742-5
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/26696553
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/13927