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Predicting Low-Risk Prostate Cancer from Transperineal Saturation Biopsies


Introduction. To assess the performance of five previously described clinicopathological definitions of low-risk prostate cancer (PC). Materials and Methods. Men who underwent radical prostatectomy (RP) for clinical stage </=T2, PSA <10 ng/mL, Gleason score <8 PC, diagnosed by transperineal template-guided saturation biopsy were included. The performance of five previously described criteria (i.e., criteria 1-5, criterion 1 stringent (Gleason score 6 + </=5 mm total max core length PC + </=3 mm max per core length PC) up to criterion 5 less stringent (Gleason score 6-7 with </=5% Gleason grade 4) was analysed to assess ability of each to predict insignificant disease in RP specimens (defined as Gleason score </=6 and total tumour volume <2.5 mL, or Gleason score 7 with </=5% grade 4 and total tumour volume <0.7 mL). Results. 994 men who underwent RP were included. Criterion 4 (Gleason score 6) performed best with area under the curve of receiver operating characteristics 0.792. At decision curve analysis, criterion 4 was deemed clinically the best performing transperineal saturation biopsy-based definition for low-risk PC. Conclusions. Gleason score 6 disease demonstrated a superior trade-off between sensitivity and specificity for clarifying low-risk PC that can guide treatment and be used as reference test in diagnostic studies.

Type Journal
ISBN 2090-3111 (Print) 2090-312X (Linking)
Authors van Leeuwen, P. J. ; Siriwardana, A. ; Roobol, M. ; Ting, F. ; Nieboer, D. ; Thompson, J. ; Delprado, W. ; Haynes, A. M. ; Brenner, P. ; Stricker, P.;
Publisher Name Prostate Cancer
Published Date 2016-01-01
Published Volume 2016
Published Pages 7105678
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version