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Diagnosis and Management of Hereditary Pancreatic Cancer

Abstract

Hereditary pancreatic cancer can be diagnosed through family history and/or a personal history of pancreatitis or clinical features suggesting one of the known pancreatic cancer predisposition syndromes. This chapter describes the currently known hereditary pancreatic cancer predisposition syndromes, including Peutz-Jeghers syndrome, familial atypical multiple mole melanoma, hereditary breast and ovarian cancer, Li-Fraumeni syndrome, hereditary non-polyposis colon cancer and familial adenomatous polyposis. Strategies for genetic testing for hereditary pancreatic cancer and the appropriate options for surveillance and cancer risk reduction are discussed. Finally, ongoing research and future directions in the diagnosis and management of hereditary pancreatic cancer will be considered.

Type Journal
ISBN 0080-0015 (Print) 0080-0015 (Linking)
Authors Humphris, J. L.; Biankin, A. V.;
Responsible Garvan Author (missing name)
Publisher Name Recent Results Cancer Res
Published Date 2016-01-01
Published Volume 205
Published Pages 61-83
Status Published in-print
URL link to publisher's version http://www.ncbi.nlm.nih.gov/pubmed/27075349
OpenAccess link to author's accepted manuscript version https://publications.gimr.garvan.org.au/open-access/13951