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The role of chemokine receptors in primary, effector, and memory immune responses


The immune system is composed of single cells, and its function is entirely dependent on the capacity of these cells to traffic, localize within tissues, and interact with each other in a precisely coordinated fashion. There is growing evidence that the large families of chemokines and chemokine receptors provide a flexible code for regulating cell traffic and positioning in both homeostatic and inflammatory conditions. The regulation of chemokine receptor expression during development and following cell activation explains the complex migratory pathways taken by dendritic cells, T and B lymphocytes, providing new insights into the mechanisms that control priming, effector function, and memory responses.

Type Journal
ISBN 0732-0582 (Print)
Authors Sallusto, F.;Mackay, C. R.;Lanzavecchia, A. :
Publisher Name Annual Review of Immunology
Published Date 2000-01-01
Published Volume 18
Published Pages 593-620
Status Published in-print
URL link to publisher's version