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Memory B cells: total recall


Immunological memory is a cornerstone of adaptive immune responses in higher vertebrates. The remarkable ability to generate memory cells following Ag exposure, in the context of natural infection or immunization, provides long-lived protection against infectious diseases, often for the hosts’ lifetime. Indeed, the generation of memory B cells and longlived plasma cells underpins the success of most vaccines. The concept of immunological memory is not new—it was first proposed nearly 2500 years ago. While our understanding of the complexities of humoral and cell-mediated memory continues to evolve, important aspects of this process remain unresolved. Here, we will provide an overview of recent advances in B-cell memory in mice and humans, and in health and disease.

Type Journal
Authors Phan, TG.; Tangye, SG.
Responsible Garvan Author Prof Stuart Tangye
Published Date 2017-03-28
Published Volume 45
Published Pages 130-140
Status Published in-print
DOI 10.1016/j.coi.2017.03.005
OpenAccess link to author's accepted manuscript version