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Plasma cell and memory B cell differentiation from the germinal center.


Germinal centers (GCs) form in secondary lymphoid tissues in response to antigenic challenge and are the site of somatic hypermutation, generating GC B cells with increasing affinity for the inciting agent that are positively selected over time. However, it is not until GC B cells differentiate into memory B cells and plasma cells and egress from the GC back into the circulation that effective long-lived humoral immunity is conferred upon the host. Here we review what is known about the signals that initiate the transition from a GC B cell into the memory B cell and plasma cell compartments and the downstream transcriptional regulation of these processes.

Type Journal
Authors Suan, D.; Sundling, C.; Brink, R.
Responsible Garvan Author Prof Robert Brink
Published Date 2017-04-01
Published Volume 45
Published Pages 97-102
Status Published in-print
DOI 10.1016/j.coi.2017.03.006
OpenAccess link to author's accepted manuscript version