Publications

Publications Search

Search for publications by author
Search for publications by abstract keyword(s)

Pathogenic CD4+ T cells regulating B-cell differentiation in autoimmunity: not exactly Tfh cells.

Abstract

T follicular helper (Tfh) cells are typically defined by the expression of CXCR5, PD-1 and BCL-6, and their ability to promote the differentiation of B cells into antibody (Ab)-producing plasma cells.1, 2 In a recent article in Nature, Brenner and colleagues described a putative pathogenic population of B-helper CD4+ T cells in tissues from patients with rheumatoid arthritis (RA).3 Curiously, while these cells expressed high levels of PD-1 and promoted B-cell differentiation, they lacked CXCR5 and BCL-6, suggesting they represent a novel subset of effector CD4+ T cells.

Type Journal
Authors Tangye, SG.
Responsible Garvan Author Prof Stuart Tangye
Publisher Name IMMUNOLOGY AND CELL BIOLOGY
Published Date 2017-05-31
Published Volume 95
Published Pages 419-421
Status Published in-print
DOI 10.1038/icb.2017.20