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The TORC that Gets the GC Cycling


The signaling pathways regulating positive selection in germinal centers (GCs) are incompletely understood. Ersching et al. (2017) identify a critical but temporal role for the action of the kinase mechanistic target of rapamycin complex (mTORC1), which promotes key changes in GC B cells and thereby facilitates affinity maturation.

Type Journal
Authors Deenick, EK.; Tangye, SG.
Responsible Garvan Author Prof Stuart Tangye
Publisher Name IMMUNITY
Published Date 2017-07-20
Published Volume 46
Published Pages 974-976
Status Published in-print
DOI 10.1016/j.immuni.2017.06.003
OpenAccess link to author's accepted manuscript version