The TORC that Gets the GC Cycling
The signaling pathways regulating positive selection in germinal centers (GCs) are incompletely understood. Ersching et al. (2017) identify a critical but temporal role for the action of the kinase mechanistic target of rapamycin complex (mTORC1), which promotes key changes in GC B cells and thereby facilitates affinity maturation.
|Authors||Deenick, EK.; Tangye, SG.|
|Responsible Garvan Author|