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Fracture Burden: What Two and a Half Decades of Dubbo Osteoporosis Epidemiology Study Data Reveal About Clinical Outcomes of Osteoporosis


PURPOSE OF THE REVIEW: This review aims to highlight important clinical findings from the over 25 year-long Dubbo Osteoporosis Epidemiology Study particularly focusing on outcomes post fracture. RECENT FINDINGS: Every low trauma fracture in the elderly is associated with an increased risk of a subsequent fracture, with a higher risk in men than women. All major or proximal fractures and even minor fractures in the very elderly or minor fractures that are then followed by re-fracture are associated with premature mortality, greatest in the first 5 years post fracture. Having a subsequent fracture further increases this high mortality risk, but if an individual survives the high risk period, their risk returns to that of the background population. Non-hip non-vertebral fractures account for a significant proportion of the premature mortality. Despite an improvement in overall health and population mortality over the years, excess mortality post fracture has not changed in the last 2 decades. All low trauma, fractures in the elderly herald a high risk of poor outcomes, particularly in the first few years post fracture. Early intervention should be initiated.

Type Journal
ISBN 1544-2241 (Electronic) 1544-1873 (Linking)
Authors Center, J. R.
Responsible Garvan Author Prof Jacqueline Center
Publisher Name Current Osteoporosis Reports
Published Date 2017-03-31
Published Volume 15
Published Issue 2
Published Pages 88-95
Status Published in-print
DOI 10.1007/s11914-017-0352-5
URL link to publisher's version