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Delineating the Relationship Between Leptin, Fat Mass, and Bone Mineral Density: A Mediation Analysis

Abstract

To test the hypothesis that the relationship between fat mass (FM) and bone mineral density (BMD) is mediated by leptin. The study involved 611 individuals aged 20-89 years who were randomly sampled from Ho Chi Minh City (Vietnam). BMD at the femoral neck (FN), lumbar spine (LS), and whole body (WB) was measured by DXA. Lean mass and FM were derived from the WB DXA scan. Leptin was measured by ELISA (DRG Diagnostics, Germany). The regression method was used to partition the variance of leptin and FM on BMD. The mediated effect of leptin was analyzed by the mediation analysis model. In the multiple linear regression, leptin, FM, and age collectively accounted for ~34 % variation in FNBMD in men and women. However, only 0.5 % of this explained variance was due to leptin. Of the total effect of FM on FNBMD, the mediated effect of leptin accounted for 6.1 % (P = 0.38) in men and 7.1 % (P = 0.99) in women. The same trend was observed for LS and WBBMD. These data suggest that greater FM is associated with greater BMD, but the association is not mediated by leptin, and that leptin has a non-significant influence on bone mass.

Type Journal
ISBN 1432-0827 (Electronic) 0171-967X (Linking)
Authors Ho-Pham, L. T.; Lai, T. Q.; Nguyen, U. D.; Bui, Q. V.; Nguyen, T. V.
Garvan Authors Prof Tuan Nguyen
Publisher Name CALCIFIED TISSUE INT
Published Date 2017-01-09 00:00:00
Published Volume 100
Published Issue 1
Published Pages 13-19
URL https://www.ncbi.nlm.nih.gov/pubmed/27722770
Status Published in-print