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BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population

Abstract

The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor-triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population.

Type Journal
ISBN 0022-1007 (Print)
Authors Thompson, J. S.;Schneider, P.;Kalled, S. L.;Wang, L.;Lefevre, E. A.;Cachero, T. G.;MacKay, F.;Bixler, S. A.;Zafari, M.;Liu, Z. Y.;Woodcock, S. A.;Qian, F.;Batten, M.;Madry, C.;Richard, Y.;Benjamin, C. D.;Browning, J. L.;Tsapis, A.;Tschopp, J.;Ambrose, C. :
Publisher Name J EXP MED
Published Date 2000-01-01 00:00:00
Published Volume 192
Published Issue 1
Published Pages 129-35
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=10880534
Status Published In-print