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The Dimensions, Dynamics, and Relevance of the Mammalian Noncoding Transcriptome


The combination of pervasive transcription and prolific alternative splicing produces a mammalian transcriptome of great breadth and diversity. The majority of transcribed genomic bases are intronic, antisense, or intergenic to protein-coding genes, yielding a plethora of short and long non-protein-coding regulatory RNAs. Long noncoding RNAs (lncRNAs) share most aspects of their biogenesis, processing, and regulation with mRNAs. However, lncRNAs are typically expressed in more restricted patterns, frequently from enhancers, and exhibit almost universal alternative splicing. These features are consistent with their role as modular epigenetic regulators. We describe here the key studies and technological advances that have shaped our understanding of the dimensions, dynamics, and biological relevance of the mammalian noncoding transcriptome.

Type Journal
ISBN 0168-9525 (Print) 0168-9525 (Linking)
Authors Deveson, I. W.; Hardwick, S. A.; Mercer, T. R.; Mattick, J. S.
Responsible Garvan Author Prof John Mattick
Published Date 2017-07-01
Published Volume 33
Published Issue 7
Published Pages 464-478
Status Published in-print
DOI 10.1016/j.tig.2017.04.004
URL link to publisher's version
OpenAccess link to author's accepted manuscript version