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Arginine methylation catalyzed by PRMT1 is required for B cell activation and differentiation

Abstract

Arginine methylation catalyzed by protein arginine methyltransferases (PRMT) is a common post-translational modification in mammalian cells, regulating many important functions including cell signalling, proliferation and differentiation. Here we show the role of PRMT1 in B-cell activation and differentiation. PRMT1 expression and activity in human and mouse peripheral B cells increases in response to in vitro or in vivo activation. Deletion of the Prmt1 gene in mature B cells establishes that although the frequency and phenotype of peripheral B cell subsets seem unaffected, immune responses to T-cell-dependent and -independent antigens are substantially reduced. In vitro activation of Prmt1-deficient B cells with a variety of mitogens results in diminished proliferation, differentiation and survival, effects that are correlated with altered signal transduction from the B cell receptor. Thus PRMT1 activity in B cells is required for correct execution of multiple processes that in turn are necessary for humoral immunity.PRMT1 is an arginine methyltransferase involved in a variety of cell functions. Here the authors delete PRMT1 specifically in mature B cells to show the importance of arginine methylation for B cell proliferation, differentiation and survival, and thereby for humoral immunity.

Type Journal
ISBN 2041-1723 (Electronic) 2041-1723 (Linking)
Authors Infantino, S.; Light, A.; O'Donnell, K.; Bryant, V.; Avery, D. T.; Elliott, M.; Tangye, S. G.; Belz, G.; Mackay, F.; Richard, S.; Tarlinton, D.
Responsible Garvan Author Prof Stuart Tangye
Publisher Name Nature Communications
Published Date 2017-10-12
Published Volume 8
Published Issue 1
Published Pages 891
Status Published in-print
DOI 10.1038/s41467-017-01009-1
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/29026071