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Charting the unknown epitranscriptome

Abstract

RNA modifications can alter RNA structure-function relationships and various cellular processes. However, the genomic distribution and biological roles of most RNA modifications remain uncharacterized. Here, we propose using phage display antibody technology and direct sequencing through nanopores to facilitate systematic interrogation of the distribution, location and dynamics of RNA modifications.

Type Letter
ISBN 1471-0080 (Electronic) 1471-0072 (Linking)
Authors Novoa, E. M.; Mason, C. E.; Mattick, J. S.
Responsible Garvan Author Prof John Mattick
Publisher Name NATURE REVIEWS MOLECULAR CELL BIOLOGY
Published Date 2017-06-01
Published Volume 18
Published Issue 6
Published Pages 339-340
Status Published in-print
DOI 10.1038/nrm.2017.49
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/28488699