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Chronic Sucralose or L-Glucose Ingestion Does Not Suppress Food Intake


Despite widespread consumption of non-nutritive sweeteners (NNSs), the impact of manipulating the perceived sweetness of food is unclear. Previously we reported that chronic consumption of the NNSs sucralose or L-glucose led to increased calories consumed post-exposure; however, a recent study suggested this effect occurs because NNSs acutely suppress food intake, leading to a caloric debt. Here we show that acute ingestion of sucralose in the context of a low-carbohydrate diet causes a pronounced increase in calories consumed. Moreover, neither sucralose nor L-glucose had a lasting effect on food intake during chronic exposure; however, both NNSs enhance food intake post-exposure. Together these data confirm that sucralose and L-glucose promote food intake under a variety of experimental conditions.

Type Letter
ISBN 1932-7420 (Electronic) 1550-4131 (Linking)
Authors Wang, Q. P.; Simpson, S. J.; Herzog, H.; Neely, G. G.
Responsible Garvan Author Prof Herbert Herzog
Publisher Name Cell Metabolism
Published Date 2017-08-31
Published Volume 26
Published Issue 2
Published Pages 279-280
Status Published in-print
DOI 10.1016/j.cmet.2017.07.002
URL link to publisher's version
OpenAccess link to author's accepted manuscript version