Chronic Sucralose or L-Glucose Ingestion Does Not Suppress Food Intake
Despite widespread consumption of non-nutritive sweeteners (NNSs), the impact of manipulating the perceived sweetness of food is unclear. Previously we reported that chronic consumption of the NNSs sucralose or L-glucose led to increased calories consumed post-exposure; however, a recent study suggested this effect occurs because NNSs acutely suppress food intake, leading to a caloric debt. Here we show that acute ingestion of sucralose in the context of a low-carbohydrate diet causes a pronounced increase in calories consumed. Moreover, neither sucralose nor L-glucose had a lasting effect on food intake during chronic exposure; however, both NNSs enhance food intake post-exposure. Together these data confirm that sucralose and L-glucose promote food intake under a variety of experimental conditions.
|ISBN||1932-7420 (Electronic) 1550-4131 (Linking)|
|Authors||Wang, Q. P.; Simpson, S. J.; Herzog, H.; Neely, G. G.|
|Responsible Garvan Author|
|Publisher Name||Cell Metabolism|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/28768164|