Transplantation sites for porcine islets
AIMS/HYPOTHESIS: Xenotransplantation has great potential to provide beta cell replacement and thereby provide a cure for large numbers of people with type 1 diabetes. Crucial to the success of xenotransplantation is establishment of the most viable sites for transplantation. METHODS: We compared porcine islet tissue transplanted into kidney, liver and spleen in pig recipients as assessed by blood glucose levels and IVGTT. RESULTS: Kidney was the superior site for porcine islet tissue transplantation, followed by liver then spleen. This was demonstrated by IVGTTs showing significant difference between the peak glucose levels: 22.8 +/- 2.9 mmol/l for kidney compared with 26.8 +/- 1.3 mmol/l for spleen and 24.7 +/- 1.7 mmol/l for liver. CONCLUSIONS/INTERPRETATION: Kidney grafts are not as feasible in humans and liver results were relatively poorer than spleen. For islet transplantation to be viable and successful in the longer term, there remains a need for future investigation of alternative sites.
|ISBN||1432-0428 (Electronic) 0012-186X (Linking)|
|Authors||Stokes, R. A.; Simond, D. M.; Burns, H.; Patel, A. T.; O'Connell, P. J.; Gunton, J. E.; Hawthorne, W. J.|
|Responsible Garvan Author|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/28730558|