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Transplantation sites for porcine islets


AIMS/HYPOTHESIS: Xenotransplantation has great potential to provide beta cell replacement and thereby provide a cure for large numbers of people with type 1 diabetes. Crucial to the success of xenotransplantation is establishment of the most viable sites for transplantation. METHODS: We compared porcine islet tissue transplanted into kidney, liver and spleen in pig recipients as assessed by blood glucose levels and IVGTT. RESULTS: Kidney was the superior site for porcine islet tissue transplantation, followed by liver then spleen. This was demonstrated by IVGTTs showing significant difference between the peak glucose levels: 22.8 +/- 2.9 mmol/l for kidney compared with 26.8 +/- 1.3 mmol/l for spleen and 24.7 +/- 1.7 mmol/l for liver. CONCLUSIONS/INTERPRETATION: Kidney grafts are not as feasible in humans and liver results were relatively poorer than spleen. For islet transplantation to be viable and successful in the longer term, there remains a need for future investigation of alternative sites.

Type Journal
ISBN 1432-0428 (Electronic) 0012-186X (Linking)
Authors Stokes, R. A.; Simond, D. M.; Burns, H.; Patel, A. T.; O'Connell, P. J.; Gunton, J. E.; Hawthorne, W. J.
Responsible Garvan Author (missing name)
Published Date 2017-10-31
Published Volume 60
Published Issue 10
Published Pages 1972-1976
Status Published in-print
DOI 10.1007/s00125-017-4363-7
URL link to publisher's version