IL-2 prevents deletion of developing T-regulatory cells in the thymus
In the thymus, strongly self-reactive T cells may undergo apoptotic deletion or differentiate into Foxp3+ T-regulatory (T-reg) cells. Mechanisms that partition T cells into these two fates are unclear. Here, we show that IL-2 signalling is required to prevent deletion of CD4+ CD8- CCR7+ Helios+ thymocytes poised to upregulate Foxp3. The deletion prevented by IL-2 signalling is Foxp3 independent and occurs later in thymocyte development than the deletion that is prevented by Card11 signalling. Our results distinguish two bottlenecks at which strongly self-reactive thymocytes undergo deletion or progress to the next stage of T-reg differentiation; Card11 regulates the first bottleneck and IL-2 regulates the second.
|ISBN||1476-5403 (Electronic) 1350-9047 (Linking)|
|Authors||Hu, D. Y.; Wirasinha, R. C.; Goodnow, C. C.; Daley, S. R.|
|Responsible Garvan Author||Prof Christopher Goodnow|
|Publisher Name||CELL DEATH AND DIFFERENTIATION|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/28362433|