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Smoke-Induced Changes to the Epigenome Provide Fertile Ground for Oncogenic Mutation

Abstract

How genetic and epigenetic events synergize to generate the oncogenic state is not well understood. In this issue of Cancer Cell, Vaz et al. provide compelling evidence that exposure to chronic cigarette smoke causes progressive epigenetic alterations that prime for key genetic events to drive the development of lung cancer.

Type Journal
ISBN 1878-3686 (Electronic) 1535-6108 (Linking)
Authors Clark, S. J.; Molloy, P. L.
Responsible Garvan Author Prof Susan Clark
Publisher Name CANCER CELL
Published Date 2017-09-30 00:00:00
Published Volume 32
Published Issue 3
Published Pages 278-280
Status Published in-print
DOI 10.1016/j.ccell.2017.08.016
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/28898692