Publications Search

Search for publications by author
Search for publications by abstract keyword(s)

AR signaling and the PI3K pathway in prostate cancer


Prostate cancer is a leading cause of cancer-related death in men worldwide. Aberrant signaling in the androgen pathway is critical in the development and progression of prostate cancer. Despite ongoing reliance on androgen receptor (AR) signaling in castrate resistant disease, in addition to the development of potent androgen targeting drugs, patients invariably develop treatment resistance. Interactions between the AR and PI3K pathways may be a mechanism of treatment resistance and inhibitors of this pathway have been developed with variable success. Herein we outline the role of the PI3K pathway in prostate cancer and, in particular, its association with androgen receptor signaling in the pathogenesis and evolution of prostate cancer, as well as a review of the clinical utility of PI3K targeting.

Type Journal
ISBN 2072-6694 (Linking)
Authors Crumbaker, M.; Khoja, L.; Joshua, A. M.
Responsible Garvan Author Prof Anthony Joshua
Publisher Name Cancers
Published Date 2017-04-15
Published Volume 9
Published Issue 4
Published Pages 34
Status Published in-print
DOI 10.3390/cancers9040034
URL link to publisher's version
OpenAccess link to author's accepted manuscript version