Use of common analgesic medications and ovarian cancer survival: results from a pooled analysis in the Ovarian Cancer Association Consortium
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) have been associated with improved survival in some cancers, but evidence for ovarian cancer is limited. METHODS: Pooling individual-level data from 12 Ovarian Cancer Association Consortium studies, we evaluated the association between self-reported, pre-diagnosis use of common analgesics and overall/progression-free/disease-specific survival among 7694 women with invasive epithelial ovarian cancer (4273 deaths). RESULTS: Regular analgesic use (at least once per week) was not associated with overall survival (pooled hazard ratios, pHRs (95% confidence intervals): aspirin 0.96 (0.88-1.04); non-aspirin NSAIDs 0.97 (0.89-1.05); acetaminophen 1.01 (0.93-1.10)), nor with progression-free/disease-specific survival. There was however a survival advantage for users of any NSAIDs in studies clearly defining non-use as less than once per week (pHR=0.89 (0.82-0.98)). CONCLUSIONS: Although this study did not show a clear association between analgesic use and ovarian cancer survival, further investigation with clearer definitions of use and information about post-diagnosis use is warranted.British Journal of Cancer advance online publication, 28 March 2017; doi:10.1038/bjc.2017.68 www.bjcancer.com.
|ISBN||1532-1827 (Electronic) 0007-0920 (Linking)|
|Authors||Dixon, S. C.; Nagle, C. M.; Wentzensen, N.; Trabert, B.; Beeghly-Fadiel, A.; Schildkraut, J. M.; Moysich, K. B.; deFazio, A.; Australian Ovarian Cancer Study, Group; Risch, H. A.; Rossing, M. A.; Doherty, J. A.; Wicklund, K. G.; Goodman, M. T.; Modugno, F.; Ness, R. B.; Edwards, R. P.; Jensen, A.; Kjaer, S. K.; Hogdall, E.; Berchuck, A.; Cramer, D. W.; Terry, K. L.; Poole, E. M.; Bandera, E. V.; Paddock, L. E.; Anton-Culver, H.; Ziogas, A.; Menon, U.; Gayther, S. A.; Ramus, S. J.; Gentry-Maharaj, A.; Pearce, C. L.; Wu, A. H.; Pike, M. C.; Webb, P. M.|
|Publisher Name||British Journal of Cancer|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/28350790|
|OpenAccess link to author's accepted manuscript version||https://publications.gimr.garvan.org.au/open-access/14231|