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The regulatory role of long noncoding RNAs in cancer

Abstract

With the advances in genomic analysis technologies, especially next-generation RNA sequencing, a large number of new transcripts have been discovered, leading to better understanding of long noncoding RNAs (lncRNAs). Recent investigations have provided firm evidence for the critical roles of lncRNAs in chromatin modification, gene transcription, RNA splicing, RNA transport and translation. In vitro and in vivo studies have also proven that aberrant lncRNA expression is essential for the initiation and progression of cancers. Due to their unique tissue- and cancer-specific expression profiles, aberrant expression of lncRNAs can be used as reliable prognostic markers for cancer diagnoses and treatment stratification, and lncRNAs are novel therapeutic targets with high therapeutic windows.

Type Journal
ISBN 1872-7980 (Electronic) 0304-3835 (Linking)
Authors Tang, Y.; Cheung, B. B.; Atmadibrata, B.; Marshall, G. M.; Dinger, M. E.; Liu, P. Y.; Liu, T.
Responsible Garvan Author A/Prof Marcel Dinger
Publisher Name CANCER LETTERS
Published Date 2017-04-10 00:00:00
Published Volume 391
Published Pages 12-19
Status Published in-print
DOI 10.1016/j.canlet.2017.01.010
URL link to publisher's version https://www.ncbi.nlm.nih.gov/pubmed/28111137