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History of comorbidities and survival of ovarian cancer patients, results from the Ovarian Cancer Association Consortium


Background: Comorbidities can affect survival of ovarian cancer patients by influencing treatment efficacy. However, little evidence exists on the association between individual concurrent comorbidities and prognosis in ovarian cancer patients.Methods: Among patients diagnosed with invasive ovarian carcinoma who participated in 23 studies included in the Ovarian Cancer Association Consortium, we explored associations between histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, and neurological diseases and overall and progression-free survival. Using Cox proportional hazards regression models adjusted for age at diagnosis, stage of disease, histology, and study site, we estimated pooled HRs and 95% confidence intervals to assess associations between each comorbidity and ovarian cancer outcomes.Results: None of the comorbidities were associated with ovarian cancer outcome in the overall sample nor in strata defined by histologic subtype, weight status, age at diagnosis, or stage of disease (local/regional vs. advanced).Conclusions: Histories of endometriosis; asthma; depression; osteoporosis; and autoimmune, gallbladder, kidney, liver, or neurologic diseases were not associated with ovarian cancer overall or progression-free survival.Impact: These previously diagnosed chronic diseases do not appear to affect ovarian cancer prognosis. Cancer Epidemiol Biomarkers Prev; 26(9); 1470-3. (c)2017 AACR.

Type Journal
ISBN 1538-7755 (Electronic) 1055-9965 (Linking)
Authors Minlikeeva, A. N.; Freudenheim, J. L.; Eng, K. H.; Cannioto, R. A.; Friel, G.; Szender, J. B.; Segal, B.; Odunsi, K.; Mayor, P.; Diergaarde, B.; Zsiros, E.; Kelemen, L. E.; Kobel, M.; Steed, H.; deFazio, A.; Jordan, S. J.; Fasching, P. A.; Beckmann, M. W.; Risch, H. A.; Rossing, M. A.; Doherty, J. A.; Chang-Claude, J.; Goodman, M. T.; Dork, T.; Edwards, R.; Modugno, F.; Ness, R. B.; Matsuo, K.; Mizuno, M.; Karlan, B. Y.; Goode, E. L.; Kjaer, S. K.; Hogdall, E.; Schildkraut, J. M.; Terry, K. L.; Cramer, D. W.; Bandera, E. V.; Paddock, L. E.; Kiemeney, L. A.; Massuger, Lfag; Sutphen, R.; Anton-Culver, H.; Ziogas, A.; Menon, U.; Gayther, S. A.; Ramus, S. J.; Gentry-Maharaj, A.; Pearce, C. L.; Wu, A. H.; Kupryjanczyk, J.; Jensen, A.; Webb, P. M.; Moysich, K. B.; Ovarian Cancer Association, Consortium; Australian Ovarian Cancer Study, Group
Published Date 2017-09-30
Published Volume 26
Published Issue 9
Published Pages 1470-1473
Status Published in-print
DOI 10.1158/1055-9965.EPI-17-0367
URL link to publisher's version