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Pre-metastatic niches: organ-specific homes for metastases


It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

Type Journal
ISBN 1474-1768 (Electronic) 1474-175X (Linking)
Authors Peinado, H.; Zhang, H.; Matei, I. R.; Costa-Silva, B.; Hoshino, A.; Rodrigues, G.; Psaila, B.; Kaplan, R. N.; Bromberg, J. F.; Kang, Y.; Bissell, M. J.; Cox, T. R.; Giaccia, A. J.; Erler, J. T.; Hiratsuka, S.; Ghajar, C. M.; Lyden, D.
Responsible Garvan Author A/Prof Thomas Cox
Published Date 2017-05-31
Published Volume 17
Published Issue 5
Published Pages 302-317
Status Published in-print
DOI 10.1038/nrc.2017.6
URL link to publisher's version