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Multiple Y receptors mediate pancreatic polypeptide responses in mouse colon mucosa


A functional study has been performed to characterise the Y receptors responsible for NPY, PYY and PP-stimulated responses in mouse colonic mucosal preparations. Electrogenic ion secretion was stimulated with VIP following which NPY, PYY and PP analogues were, to varying degrees, inhibitory. PYY(3-36), hPP, Gln(23)hPP and rPP were effective but less potent than full length PYY, NPY or their Pro(34)-substituted analogues, while the Y(5) agonist Ala(31), Aib(32)hNPY was the least active peptide tested. The Y(1) antagonists, BIBP3226 and BIBO3304 virtually abolished Pro(34)PYY and PYY responses while PYY(3-36) responses were selectively inhibited by the Y(2) antagonist, BIIE0246. A combination of BIBO3304 and BIIE0246 also partially attenuated hPP responses, leaving residual effects that were most probably Y(4)-mediated. Thus we conclude that Y(1), Y(2) and Y(4) receptors attenuate ion secretion in mouse colon.

Type Journal
ISBN 0196-9781 (Print)
Authors Cox, H. M.;Pollock, E. L.;Tough, I. R.;Herzog, H. :
Responsible Garvan Author Prof Herbert Herzog
Publisher Name PEPTIDES
Published Date 2001-01-01
Published Volume 22
Published Issue 3
Published Pages 445-52
Status Published in-print
URL link to publisher's version