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Regulated transport of the glucose transporter GLUT4

Abstract

In muscle and fat cells, insulin stimulates the delivery of the glucose transporter GLUT4 from an intracellular location to the cell surface, where it facilitates the reduction of plasma glucose levels. Understanding the molecular mechanisms that mediate this translocation event involves integrating our knowledge of two fundamental processes--the signal transduction pathways that are triggered when insulin binds to its receptor and the membrane transport events that need to be modified to divert GLUT4 from intracellular storage to an active plasma membrane shuttle service.

Type Journal
ISBN 1471-0072 (Print)
Authors Bryant, N. J.;Govers, R.;James, D. E. :
Publisher Name NAT REV MOL CELL BIO
Published Date 2002-01-01 00:00:00
Published Volume 3
Published Issue 4
Published Pages 267-77
URL http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=11994746
Status Published In-print