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Focal ablation of apical prostate cancer lesions with irreversible electroporation (IRE)


INTRODUCTION AND OBJECTIVE: To assess the safety, oncological and quality-of-life (QoL) outcomes of focal ablation of apical prostate cancer (PCa) lesions with irreversible electroporation (IRE). METHODS: Patients were included in the study if they had a PCa lesion within 3 mm of the apical capsule treated with IRE. The IRE procedure was performed in our institution by a single urologist. The QoL and functional data was collected prospectively from patients who provided consent using the Expanded Prostate Cancer Index Composite (EPIC). Oncological follow up included 3-month PSA levels, mpMRI at 6 months and transperineal biopsy at 1-year post treatment. RESULTS: A total of 50 patients had apical PCa lesions treated between February 2013 and September 2018. Median follow-up was 44 months. There were no Clavien-Dindo grade 3 events or higher. No perioperative complications were recorded. No significant difference was observed in the EPIC urinary or bowel QoL domain between baseline and 12-month post-treatment. One patient (2%) required one pad per day for urinary incontinence 12-month post-treatment. There was a small but significant decline in EPIC sexual QoL (65 at baseline and 59 at 12-month post-IRE). Of patient's potent pre-treatment, 94% remained potent after treatment. The median PSA nadir decreased by 71% (6.25-1.7 ng/mL). Only one patient (2.5%) had in-field residual disease on repeat biopsy. CONCLUSION: Focal ablation using IRE for PCa in the distal apex appears safe and feasible with acceptable early QoL and oncologic outcomes.

Type Journal
ISBN 1433-8726 (Electronic) 0724-4983 (Linking)
Authors Blazevski, A.; Amin, A.; Scheltema, M. J.; Balakrishnan, A.; Haynes, A. M.; Barreto, D.; Cusick, T.; Thompson, J.; Stricker, P. D.
Responsible Garvan Author Anne-Maree Haynes
Published Date 2021-04-30
Published Volume 39
Published Issue 4
Published Pages 1107-1114
Status Published in-print
DOI 10.1007/s00345-020-03275-z
URL link to publisher's version