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An optimized protocol for establishing a chronic stress model in mice


Chronic stress has adverse consequences on many organ systems and physiological processes. However, existing protocols show large variability in response and are not suitable for female mice. Here, we provide a step-by-step protocol for establishing a reliable chronic stress model in mice that can be used in a variety of physiological settings. This protocol has been tested to be effective to produce a consistent response to stress in several mouse strains (C57BL/6J, 129X1/SvJ, B6.V-Lepob/J) and both sexes. For complete details on the use and execution of this protocol, please refer to Ip et al. (2019).

Type Journal
ISBN 2666-1667 (Electronic) 2666-1667 (Linking)
Authors Ip, C. K.
Responsible Garvan Author Dr Kenny Ip
Publisher Name STAR Protocols
Published Date 2021-04-30
Published Volume 2
Published Issue 2
Published Pages 100448
Status Published in-print
DOI 10.1016/j.xpro.2021.100448
URL link to publisher's version