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BAFF: a fundamental survival factor for B cells


B-cell-activating factor of the tumour-necrosis-factor family (BAFF) enhances B-cell survival--a function that is indispensable for B-cell maturation--and has a role in enhancing immune responses. Moreover, the overexpression of BAFF results in severe autoimmune disorders in mice, and elevated serum levels of BAFF occur in some patients who have autoimmune diseases. The elucidation of the role of BAFF has set the stage for a new approach to the treatment of autoimmune disease.

Type Journal
ISBN 1474-1733 (Print)
Authors Mackay, F.;Browning, J. L. :
Publisher Name NAT REV IMMUNOL
Published Date 2002-01-01 00:00:00
Published Volume 2
Published Issue 7
Published Pages 465-75
Status Published In-print