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Single cell RNA-sequencing data generated from human pluripotent stem cell-derived lens epithelial cells


Detailed transcriptomic analyses of differentiated cell populations derived from human pluripotent stem cells is routinely used to assess the identity and utility of the differentiated cells. Here we provide single cell RNA-sequencing data obtained from ROR1-expressing lens epithelial cells (ROR1e LECs), obtained via directed differentiation of CA1 human embryonic stem cells. Analysis of the data using principal component analysis, heat maps and gene ontology assessments revealed phenotypes associated with lens epithelial cells. These data provide a resource for future characterisation of both normal and cataractous human lens biology. Corresponding morphological and functional data obtained from ROR1e LECs are reported in the associated research article "A simplified method for producing human lens epithelial cells and light-focusing micro-lenses from pluripotent stem cells " (Dewi et al., 2020).

Type Journal
ISBN 2352-3409 (Electronic) 2352-3409 (Linking)
Authors Shparberg, R.; Dewi, C. U.; Gnanasambandapillai, V.; Liyanage, L.; O'Connor, M. D.
Responsible Garvan Author (missing name)
Publisher Name Data in Brief
Published Date 2021-01-31
Published Volume 34
Published Pages 106657
Status Published in-print
DOI 10.1016/j.dib.2020.106657
URL link to publisher's version
OpenAccess link to author's accepted manuscript version