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Shared B cell memory to coronaviruses and other pathogens varies in human age groups and tissues


Vaccination and infection promote the formation, tissue distribution, and clonal evolution of B cells, which encode humoral immune memory. We evaluated pediatric and adult blood and deceased adult organ donor tissues to determine convergent antigen-specific antibody genes of similar sequences shared between individuals. B cell memory varied for different pathogens. Polysaccharide antigen-specific clones were not exclusive to the spleen. Adults had higher clone frequencies and greater class switching in lymphoid tissues than blood, while pediatric blood had abundant class-switched convergent clones. Consistent with reported serology, prepandemic children had class-switched convergent clones to severe acute respiratory syndrome coronavirus 2 with weak cross-reactivity to other coronaviruses, while adult blood or tissues showed few such clones. These results highlight the prominence of early childhood B cell clonal expansions and cross-reactivity for future responses to novel pathogens.

Type Journal
ISBN 1095-9203 (Electronic) 0036-8075 (Linking)
Authors Yang, F.; Nielsen, S. C. A.; Hoh, R. A.; Roltgen, K.; Wirz, O. F.; Haraguchi, E.; Jean, G. H.; Lee, J. Y.; Pham, T. D.; Jackson, K. J. L.; Roskin, K. M.; Liu, Y.; Nguyen, K.; Ohgami, R. S.; Osborne, E. M.; Nadeau, K. C.; Niemann, C. U.; Parsonnet, J.; Boyd, S. D.
Publisher Name SCIENCE
Published Date 2021-05-31
Published Volume 372
Published Issue 6543
Published Pages 738-741
Status Published in-print
DOI 10.1126/science.abf6648
URL link to publisher's version