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Regulation of neuropeptide Y in body microenvironments and its potential application in therapies: a review


Neuropeptide Y (NPY), one of the most abundant neuropeptides in the body, is widely expressed in the central and peripheral nervous systems and acts on the cardiovascular, digestive, endocrine, and nervous systems. NPY affects the nutritional and inflammatory microenvironments through its interaction with immune cells, brain-derived trophic factor (BDNF), and angiogenesis promotion to maintain body homeostasis. Additionally, NPY has great potential for therapeutic applications against various diseases, especially as an adjuvant therapy for stem cells. In this review, we discuss the research progress regarding NPY, as well as the current evidence for the regulation of NPY in each microenvironment, and provide prospects for further research on related diseases.

Type Journal
ISBN 2045-3701 (Print) 2045-3701 (Linking)
Authors Zhang, Y.; Liu, C. Y.; Chen, W. C.; Shi, Y. C.; Wang, C. M.; Lin, S.; He, H. F.
Publisher Name Cell and Bioscience
Published Date 2021-08-31
Published Volume 11
Published Issue 1
Published Pages 151
Status Published in-print
DOI 10.1186/s13578-021-00657-7
URL link to publisher's version