Homeostasis of Naive and Memory T Lymphocytes
Conventional CD4(+) and CD8(+) T lymphocytes comprise a mixture of naive and memory cells. Generation and survival of these T-cell subsets is under strict homeostatic control and reflects contact with self-major histocompatibility complex (MHC) and certain cytokines. Naive T cells arise in the thymus via T-cell receptor (TCR)-dependent positive selection to self-peptide/MHC complexes and are then maintained in the periphery through self-MHC interaction plus stimulation via interleukin-7 (IL-7). By contrast, memory T cells are largely MHC-independent for their survival but depend strongly on stimulation via cytokines. Whereas typical memory T cells are generated in response to foreign antigens, some arise spontaneously through contact of naive precursors with self-MHC ligands; we refer to these cells as memory-phenotype (MP) T cells. In this review, we discuss the generation and homeostasis of naive T cells and these two types of memory T cells, focusing on their relative interaction with MHC ligands and cytokines.
|ISBN||1943-0264 (Electronic) 1943-0264 (Linking)|
|Authors||Kawabe, T.; Yi, J.; Sprent, J.|
|Responsible Garvan Author||Prof Jonathan Sprent|
|Publisher Name||Cold Spring Harbor Perspectives in Biology|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/33753403|