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Oxysterols: From physiological tuners to pharmacological opportunities


Oxysterols are oxygenated forms of cholesterol generated via autooxidation by free radicals and ROS, or formed enzymically by a variety of enzymes such as those involved in the synthesis of bile acids. Although found at very low concentrations in vivo, these metabolites play key roles in health and disease, particularly in development and regulating immune cell responses, by binding to effector proteins such as LXRalpha, RORgamma and Insig and directly or indirectly regulating transcriptional programmes that affect cell metabolism and function. In this review, we summarise the routes by which oxysterols can be generated and subsequently modified to other oxysterol metabolites and highlight their diverse and profound biological functions and opportunities to alter their levels using pharmacological approaches. LINKED ARTICLES: This article is part of a themed issue on Oxysterols, Lifelong Health and Therapeutics. To view the other articles in this section visit

Type Journal
ISBN 1476-5381 (Electronic) 0007-1188 (Linking)
Authors Brown, A. J.; Sharpe, L. J.; Rogers, M. J.
Responsible Garvan Author Prof Mike Rogers
Published Date 2021-08-31
Published Volume 178
Published Issue 16
Published Pages 3089-3103
Status Published in-print
DOI 10.1111/bph.15073
URL link to publisher's version