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Psychological Stress and Functional Endometrial Disorders: Update of Mechanism Insights


The human endometrium plays a vital role in providing the site for embryo implantation and maintaining the normal development and survival of the embryo. Recent studies have shown that stress is a common factor for the development of unexplained reproductive disorders. The nonreceptive endometrium and disturbed early maternal-fetal interaction might lead to infertility including the repeated embryo implantation failure and recurrent spontaneous abortion, or late pregnancy complications, thereby affecting the quality of life as well as the psychological status of the affected individuals. Additionally, psychological stress might also adversely affect female reproductive health. In recent years, several basic and clinical studies have tried to investigate the harm caused by psychological stress to reproductive health, however, the mechanism is still unclear. Here, we review the relationship between psychological stress and endometrial dysfunction, and its consequent effects on female infertility to provide new insights for clinical therapeutic interventions in the future.

Type Journal
ISBN 1664-2392 (Print) 1664-2392 (Linking)
Authors Wu, J. X.; Lin, S.; Kong, S. B.
Responsible Garvan Author Shu Lin
Publisher Name Frontiers in Endocrinology
Published Date 2021-08-31
Published Volume 12
Published Pages 690255
Status Published in-print
DOI 10.3389/fendo.2021.690255
URL link to publisher's version