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Growth hormone in exercise: comparison of physiological and pharmacological stimuli


This study was designed to compare the serum growth hormone (GH) response with quantified exercise to that obtained with other stimuli. In eight normal males, aged 21-24 yr, we studied the serum GH response to 20 min cycle ergometer exercise at 300, 600, and 900 kpm/min on three separate occasions and compared the results with those found during sleep, insulin hypoglycemia, arginine infusion, and L-DOPA. Exercise at 900 kpm/min and insulin hypoglycemia resulted in the greatest elevations in serum GH which were significantly greater than those found with sleep, arginine or L-DOPA. The 20-min exercise at 900 kpm/min represented 75-90% of the subjects' maximal oxygen uptake and is a suitable provocative test for GH secretion. As a screening test for pituitary GH reserve, exercise compares favorably with insulin hypoglycemia and is superior to sleep, arginine, and L-DOPA.

Type Journal
ISBN 0021-8987 (Print)
Authors Sutton, J.;Lazarus, L. :
Published Date 1976-01-01
Published Volume 41
Published Issue 4
Published Pages 523-7
Status Published in-print
URL link to publisher's version
OpenAccess link to author's accepted manuscript version