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Neuropeptide Y: An Update on the Mechanism Underlying Chronic Intermittent Hypoxia-Induced Endothelial Dysfunction


Endothelial dysfunction (ED) is a core pathophysiological process. The abnormal response of vascular endothelial (VE) cells to risk factors can lead to systemic consequences. ED caused by intermittent hypoxia (IH) has also been recognized. Neuropeptide Y (NPY) is an important peripheral neurotransmitter that binds to different receptors on endothelial cells, thereby causing ED. Additionally, hypoxia can induce the release of peripheral NPY; however, the involvement of NPY and its receptor in IH-induced ED has not been determined. This review explains the definition of chronic IH and VE function, including the relationship between ED and chronic IH-related vascular diseases. The results showed that that the effect of IH on VE injury is mediated by the VE-barrier structure and endothelial cell dysfunction. These findings offer new ideas for the prevention and treatment of obstructive sleep apnea syndrome and its complications.

Type Journal
ISBN 1664-042X (Print) 1664-042X (Linking)
Authors Li, M. M.; Zheng, Y. L.; Wang, W. D.; Lin, S.; Lin, H. L.
Responsible Garvan Author Shu Lin
Publisher Name Frontiers in Physiology
Published Date 2021-08-31
Published Volume 12
Published Pages 712281
Status Published in-print
DOI 10.3389/fphys.2021.712281
URL link to publisher's version