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Dynamic regional alterations in mouse brain neuronal activity following short-term changes in energy balance


OBJECTIVE: Knowledge of the functional contribution to energy homeostatic control by different brain areas is limited. This study employed a systematic approach to identify brain regions specifically influenced by a positive energy balance. METHODS: The c-fos expression was mapped throughout the mouse brain after varying durations (24 hours to up to 14 days) of high-fat diet (HFD) exposure or after reversal from a 7-day HFD to a chow diet. In parallel, the metabolic and behavioral impacts of these treatments were examined. RESULTS: A HFD elicited rapid and pronounced compensatory responses which were, however, insufficient to overcome the impact of the positive energy balance. Rapid and dynamic responses of c-fos expression throughout the brain were seen over the course of HFD exposure, with some regions showing linear-like responses and some regions exhibiting biphasic responses. The switch from HFD to chow resulted in metabolic compensations mitigating the effects of the negative energy balance and a heightened preference for sweet taste. Interestingly, this diet switch led to a significant c-fos activation in the lateral hypothalamus, an area unresponsive to HFD intervention. CONCLUSIONS: Plasticity exists in the extended brain networks facilitating rapid adaptations dependent on energy availability. Knowledge of these critical control points may provide novel antiobesity treatment targets.

Type Journal
ISBN 1930-739X (Electronic) 1930-7381 (Linking)
Authors Kakall, Z. M.; Gopalasingam, G.; Herzog, H.; Zhang, L.
Responsible Garvan Author Dr Lei Zhang
Publisher Name Obesity
Published Date 2021-10-31
Published Volume 29
Published Issue 10
Published Pages 1650-1663
Status Published in-print
DOI 10.1002/oby.23253
URL link to publisher's version