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CD4(+) T cells that help B cells - a proposal for uniform nomenclature


T follicular helper (Tfh) cells cognately guide differentiation of antigen-primed B cells in secondary lymphoid tissues. 'Tfh-like' populations not expressing the canonical Tfh cell transcription factor BCL6 have also been described, which can aid particular aspects of B cell differentiation. Tfh and Tfh-like cells are essential for protective and pathological humoral immunity. These CD4(+) T cells that help B cells are polarized to produce diverse combinations of cytokines and chemokine receptors and can be grouped into distinct subsets that promote antibodies of different isotype, affinity, and duration, according to the nature of immune challenge. However, unified nomenclature to describe the distinct functional Tfh and Tfh-like cells does not exist. While explicitly acknowledging cellular plasticity, we propose categorizing these cell states into three groups based on phenotype and function, paired with their anatomical site of action.

Type Journal
ISBN 1471-4981 (Electronic) 1471-4906 (Linking)
Authors Eisenbarth, S. C.; Baumjohann, D.; Craft, J.; Fazilleau, N.; Ma, C. S.; Tangye, S. G.; Vinuesa, C. G.; Linterman, M. A.
Responsible Garvan Author Prof Stuart Tangye
Published Date 2021-08-31
Published Volume 42
Published Issue 8
Published Pages 658-669
Status Published in-print
DOI 10.1016/
URL link to publisher's version