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Cyclin D1 and mammary carcinoma: new insights from transgenic mouse models


Cyclin D1 is one of the most commonly overexpressed oncogenes in breast cancer, with 45-50% of primary ductal carcinomas overexpressing this oncoprotein. Targeted deletion of the gene encoding cyclin D1 demonstrates an essential role in normal mammary gland development while transgenic studies provide evidence that cyclin D1 is a weak oncogene in mammary epithelium. In a recent exciting development, Yu et al. demonstrate that cyclin D1-deficient mice are resistant to mammary carcinomas induced by c-neu and v-Ha-ras, but not those induced by c-myc or Wnt-1. These findings define a pivotal role for cyclin D1 in a subset of mammary cancers in mice and imply a functional role for cyclin D1 overexpression in human breast cancer.

Type Journal
ISBN 1465-5411 (Print)
Authors Sutherland, R. L.;Musgrove, E. A. :
Responsible Garvan Author (missing name)
Published Date 2002-01-01
Published Volume 4
Published Issue 1
Published Pages 14-7
Status Published in-print
URL link to publisher's version