Evolutionary dynamics of circular RNAs in primates
Many primate genes produce circular RNAs (circRNAs). However, the extent of circRNA conservation between closely related species remains unclear. By comparing tissue-specific transcriptomes across over 70 million years of primate evolution, we identify that within 3 million years circRNA expression profiles diverged such that they are more related to species identity than organ type. However, our analysis also revealed a subset of circRNAs with conserved neural expression across tens of millions of years of evolution. By comparing to species-specific circRNAs, we identified that the downstream intron of the conserved circRNAs display a dramatic lengthening during evolution due to the insertion of novel retrotransposons. Our work provides comparative analyses of the mechanisms promoting circRNAs to generate increased transcriptomic complexity in primates.
|ISBN||2050-084X (Electronic) 2050-084X (Linking)|
|Authors||Santos-Rodriguez, G.; Voineagu, I.; Weatheritt, R. J.|
|Responsible Garvan Author||A/Prof Robert Weatheritt|
|URL link to publisher's version||https://www.ncbi.nlm.nih.gov/pubmed/34542404|